6-(bromomethyl)-1-naphthonitrile

Base Information

• Chemical Name: 6-(bromomethyl)-1-naphthonitrile
• CAS No.: 81940-37-6
• Molecular Formula: C₁₂H₈BrN
• Molecular Weight: 246.106
• Mol file: 81940-37-6.mol

Synonyms:

Chemical Property of 6-(bromomethyl)-1-naphthonitrile

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

6-(Bromomethyl)-1-naphthonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(bromomethyl)-1-naphthonitrile

There total 3 articles about 6-(bromomethyl)-1-naphthonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

6-methyl-1-naphthonitrile (71235-73-9) → 6-(bromomethyl)-1-naphthonitrile (81940-37-6)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 3h; Heating; Irradiation;

DOI:10.1021/ja00381a023

Reference yield:

6-methylnaphthalene-1-carboxylic acid (6315-19-1) → 6-(bromomethyl)-1-naphthonitrile (81940-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) thionyl chloride, 2.) NH₄OH / 1.) reflux, 5 h, 2.) room temperature, 40 min

2: tosyl chloride / pyridine / 24 h / Heating

3: 20 percent / NBS / CCl₄ / 3 h / Heating; Irradiation

With ammonium hydroxide; N-Bromosuccinimide; thionyl chloride; p-toluenesulfonyl chloride; In pyridine; tetrachloromethane;

DOI:10.1021/ja00381a023

Reference yield:

6-methyl-1-naphthamide (81940-36-5) → 6-(bromomethyl)-1-naphthonitrile (81940-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tosyl chloride / pyridine / 24 h / Heating

2: 20 percent / NBS / CCl₄ / 3 h / Heating; Irradiation

With N-Bromosuccinimide; p-toluenesulfonyl chloride; In pyridine; tetrachloromethane;

DOI:10.1021/ja00381a023

upstream raw materials:

6-methyl-1-naphthonitrile

6-methylnaphthalene-1-carboxylic acid

6-methyl-1-naphthamide

Refernces