CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester

Base Information

Chemical Name:CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester
CAS No.:936024-96-3
Molecular Formula:C₂₃H₂₇N₃O₃
Molecular Weight:393.486
Hs Code.:
Mol file:936024-96-3.mol

Synonyms:

Suppliers and Price of CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester

Chemical Property:

Melting Point:130-137 °C
PKA:11.51±0.46(Predicted)
Density:1.16±0.1 g/cm3(Predicted)

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester

There total 12 articles about CarbaMic acid, N-[(1S)-1-[3,4-dihydro-5-Methyl-3-(2-Methylphenyl)-4-oxo-2-quinazolinyl]ethyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 936024-94-1
tert-butyl (S)-1-(5-methyl-4-(o-tolylimino)-4H-benzo[d][1,3]oxazin-2-yl)ethylcarbamate

: 936024-96-3
tert-butyl (S)-(1-(5-methyl-4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: tert-butyl (S)-1-(5-methyl-4-(o-tolylimino)-4H-benzo[d][1,3]oxazin-2-yl)ethylcarbamate; With pyrrolidine; at 20 ℃; for 18h;

With acetic acid; In acetonitrile; for 0.5h; Further stages.; Heating;
DOI:10.1021/ol070276c

Reference yield: 58.0%

: 936025-18-2
tert-butyl (S)-(1-(2-methyl-6-nitro-N-(o-tolyl)benzamido)-1-oxopropan-2-yl)carbamate

: 936024-96-3
tert-butyl (S)-(1-(5-methyl-4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: With acetic acid; zinc; at 20 ℃; for 3.5h;
DOI:10.1021/ol070276c

Reference yield:

: 936024-98-5
2-methyl-6-nitro-N-(o-tolyl)benzamide

: 936024-96-3
tert-butyl (S)-(1-(5-methyl-4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂; DMF / toluene / 2.5 h / Heating

2: 1.80 g / N,N-diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

3: 58 percent / Zn; acetic acid / 3.5 h / 20 °C

With thionyl chloride; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; zinc; In dichloromethane; toluene; 2: Mumm rearrangement;
DOI:10.1021/ol070276c