tolrestat

Base Information

• Chemical Name: tolrestat
• CAS No.: 120522-86-3
• Molecular Formula: C₁₆H₁₄F₃NO₃S
• Molecular Weight: 357.353
• Mol file: 120522-86-3.mol

Synonyms:

Chemical Property of tolrestat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tolrestat

There total 11 articles about tolrestat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-1-naphthalenecarboxylic acid methyl ester (61109-48-6) → tolrestat (120522-86-3,120522-87-4,82964-04-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 87 percent / I₂, HIO₃, H₂SO₄ / acetic acid

2: 93 percent / Cu / pyridine / 20 h / 120 °C

3: hydrolysis

4: SOCl₂

6: P₂S₅ / Heating

7: KOH

With potassium hydroxide; thionyl chloride; tetraphosphorus decasulfide; sulfuric acid; iodine; iodic acid; copper; In pyridine; acetic acid;

DOI:10.1021/jm00369a003

Reference yield:

5-iodo-6-methoxy-1-naphthalenecarboxylic acid methyl ester (84532-68-3) → tolrestat (120522-86-3,120522-87-4,82964-04-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / Cu / pyridine / 20 h / 120 °C

2: hydrolysis

3: SOCl₂

5: P₂S₅ / Heating

6: KOH

With potassium hydroxide; thionyl chloride; tetraphosphorus decasulfide; copper; In pyridine;

DOI:10.1021/jm00369a003

Reference yield:

5-Methyl-2-methoxy-1-(trifluoromethyl)naphthalene (85674-78-8) → tolrestat (120522-86-3,120522-87-4,82964-04-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 55 percent / KMnO₄

2: SOCl₂

4: P₂S₅ / Heating

5: KOH

With potassium hydroxide; potassium permanganate; thionyl chloride; tetraphosphorus decasulfide;

DOI:10.1021/jm00369a003

upstream raw materials:

tolrestat methyl ester

6-methoxy-1-naphthalenecarboxylic acid methyl ester

5-Methyl-2-methoxy-1-(trifluoromethyl)naphthalene

6-methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid

Downstream raw materials:

6-methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid

N-<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>oxomethyl>-N-methylglycine

5-(Carboxymethyl-methyl-carbamoyl)-2-methoxy-naphthalene-1-carboxylic acid

N-<(5-carboxyl)-6-methoxy-1-naphtalenyl>-thiomethyl-N-methylglycine

Refernces

• 1、 -. "USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS". . . Retrieved 2008/06/13.