(+/-)-asteltoxin

Base Information

Chemical Name:(+/-)-asteltoxin
CAS No.:87480-12-4
Molecular Formula:C₂₃H₃₀O₇
Molecular Weight:418.487
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-asteltoxin

Chemical Property:

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Technology Process of (+/-)-asteltoxin

There total 18 articles about (+/-)-asteltoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 90623-39-5
4(R,S),6(R,S)-dihydroxy-5(R,S),6-dimethyl-7(R,S)-ethyl-3(R,S)-(5-hydroxy-6-(4-methoxy-5-methyl-α-pyron-6-yl)-(E,E)-hexa-1,3-dien-1-yl)-1(S,R)-2,8-dioxabicyclo<3.3.0>octane

: 79663-49-3,87480-12-4
(+/-)-asteltoxin

Guidance literature:: With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; for 12h;
DOI:10.1021/ja00327a020

Reference yield:

: 20843-07-6
3,4-dimethylfuran

: 79663-49-3,87480-12-4
(+/-)-asteltoxin

Guidance literature:: Multi-step reaction with 15 steps

1: 63 percent / benzene; diethyl ether / 6 h / Irradiation

2: 80 percent / NaHCO₃ / CH₂Cl₂

3: 3 N HCl / tetrahydrofuran

4: MgSO₄ / CH₂Cl₂

5: tetrahydrofuran / 48 h / Ambient temperature

6: CuSO₄, CSA

7: 98 percent / Li, NH₃ / diethyl ether

8: 1) o-NO₂C₆H₄SeCN, Bu₃P, 2) H₂O₂ / 1) THF, 2) THF

9: O₃, NaHCO₃ / CH₂Cl₂; methanol / -78 °C

10: Me₂S / CH₂Cl₂; methanol / 3 h / Ambient temperature

11: 185 mg / 1.9 M n-BuLi/hexane / tetrahydrofuran / 0.67 h / -78 °C

12: 77 percent / camphorsulfonic acid / CH₂Cl₂ / 8 h / Ambient temperature

13: 1) CF₃CO₂COCH₃, 2,6-lutidine, 2) CaCO₃, HgCl₂ / 1) Ac₂O, r.t., 1 h, 2) MeCN, H₂O, r.t., 2 h

14: 80 percent / LDA-HMPA / tetrahydrofuran / 0.25 h / -78 °C

15: 82 percent / p-toluenesulfonyl chloride, 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / 12 h

With 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; ortho-nitrophenyl selenocyanate; dimethylsulfide; hexane; tributylphosphine; trifluoroacetic anhydride; camphor-10-sulfonic acid; ammonia; dihydrogen peroxide; lithium; sodium hydrogencarbonate; magnesium sulfate; ozone; copper(II) sulfate; triethylamine; p-toluenesulfonyl chloride; calcium carbonate; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00327a020

Reference yield:

: 922-65-6
divinylcarbinol

: 79663-49-3,87480-12-4
(+/-)-asteltoxin

Guidance literature:: Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) THF, -78 deg C, 2) -50 --> 0 deg C

2: 185 mg / 1.9 M n-BuLi/hexane / tetrahydrofuran / 0.67 h / -78 °C

3: 77 percent / camphorsulfonic acid / CH₂Cl₂ / 8 h / Ambient temperature

4: 1) CF₃CO₂COCH₃, 2,6-lutidine, 2) CaCO₃, HgCl₂ / 1) Ac₂O, r.t., 1 h, 2) MeCN, H₂O, r.t., 2 h

5: 80 percent / LDA-HMPA / tetrahydrofuran / 0.25 h / -78 °C

6: 82 percent / p-toluenesulfonyl chloride, 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / 12 h

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; hexane; trifluoroacetic anhydride; camphor-10-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; calcium carbonate; mercury dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00327a020