Technology Process of 8-bromo-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl acetate
There total 6 articles about 8-bromo-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-bromo-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -70 ℃;
for 0.25h;
Inert atmosphere;
acetic anhydride;
In
tetrahydrofuran;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / methanol / 5 h / Reflux
2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 2 h / 20 °C / 2585.81 Torr
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 15 h / -5 - 20 °C
3.2: pH 2 - 3
4.1: PPA / chlorobenzene / 15 h / 80 °C
5.1: bromine / diethyl ether / 2 h
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
6.2: 0.5 h / -78 - 0 °C
With
lithium hydroxide monohydrate; potassium tert-butylate; water; hydrogen; bromine; lithium hexamethyldisilazane;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; chlorobenzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 2 h / 20 °C / 2585.81 Torr
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 15 h / -5 - 20 °C
2.2: pH 2 - 3
3.1: PPA / chlorobenzene / 15 h / 80 °C
4.1: bromine / diethyl ether / 2 h
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
5.2: 0.5 h / -78 - 0 °C
With
lithium hydroxide monohydrate; water; hydrogen; bromine; lithium hexamethyldisilazane;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; chlorobenzene;
