5-amino-2',7'-dichlorofluorescein

Base Information

• Chemical Name: 5-amino-2',7'-dichlorofluorescein
• CAS No.: 149541-14-0
• Molecular Formula: C₂₀H₁₁Cl₂NO₅
• Molecular Weight: 416.217
• Mol file: 149541-14-0.mol

Synonyms:

Chemical Property of 5-amino-2',7'-dichlorofluorescein

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-2',7'-dichlorofluorescein

There total 4 articles about 5-amino-2',7'-dichlorofluorescein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

5-nitro-2',7'-dichlorofluorescein (149541-13-9) → 5-amino-2',7'-dichlorofluorescein (149541-14-0)

Guidance literature:

With sodiumsulfide nonahydrate; In water; at 60 ℃; for 2h;

DOI:10.1016/j.tet.2020.131087

Reference yield:

sodium hydrogensulfide + 5-nitro-2',7'-dichlorofluorescein (149541-13-9) → 5-amino-2',7'-dichlorofluorescein (149541-14-0)

Guidance literature:

With sodium sulfide nonahydrate; In hydrogenchloride; water;

Reference yield:

4-Chlororesorcinol (95-88-5) → 5-amino-2',7'-dichlorofluorescein (149541-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 11 h / 100 °C

1.2: 4 h / 80 °C

2.1: sodiumsulfide nonahydrate / water / 2 h / 60 °C

With sodiumsulfide nonahydrate; In water;

DOI:10.1016/j.tet.2020.131087

upstream raw materials:

5-nitro-2',7'-dichlorofluorescein

4-nitrophthalic anhydride

4-Chlororesorcinol