4-bromo-2-nitropyridine

Base Information

• Chemical Name: 4-bromo-2-nitropyridine
• CAS No.: 909712-10-3
• Molecular Formula: C₅H₃BrN₂O₂
• Molecular Weight: 202.995
• Mol file: 909712-10-3.mol

Synonyms:

Chemical Property of 4-bromo-2-nitropyridine

Chemical Property:

• Boiling Point: 305.1±22.0 °C(Predicted)
• PKA: -3.84±0.10(Predicted)
• Density: 1.833±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-nitropyridine

There total 1 articles about 4-bromo-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-amino-4-bromopyridine (84249-14-9) → 4-bromo-2-nitropyridine (909712-10-3)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2018.07.045

Reference yield:

4-bromo-2-nitropyridine (909712-10-3) → C19H14F(18)FN4O

Guidance literature:

Multi-step reaction with 4 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.75 h / Inert atmosphere; Reflux

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

4: [2.2.2]cryptande; potassium carbonate; [18F]fluoride ion, cyclotron produced, NCA / dimethyl sulfoxide; water; acetonitrile / 150 - 155 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; caesium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.bmc.2018.07.045

Reference yield:

4-bromo-2-nitropyridine (909712-10-3) → N-(6-(2-fluorophenyl)-5-(2-nitropyridine-4-yl)pyrazine-2-yl)cyclopropanecarboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.75 h / Inert atmosphere; Reflux

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; water;

DOI:10.1016/j.bmc.2018.07.045

upstream raw materials:

2-amino-4-bromopyridine

Refernces