Technology Process of (+/-)-3α,4β-Dihydroxy-1α,2α-epoxy-1,2,3,4-tetrahydrobenzacridine
There total 10 articles about (+/-)-3α,4β-Dihydroxy-1α,2α-epoxy-1,2,3,4-tetrahydrobenzacridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Na / pentan-1-ol / 1 h / Heating
2: 10N aq. HCl, FeCl3 / 2 h / Heating
3: 1.) NBS, AIBN; 2.) Li2CO3, LiF; 3.) I2
4: 98 percent / NBS, AIBN / CCl4 / 30 h / 70 - 75 °C
5: 82 percent / Li2CO3, LiF / hexamethylphosphoric acid triamide / 6 h / 90 - 95 °C
6: 85 percent / NH3(gas)/MeOH / methanol; tetrahydrofuran / 2 h / Ambient temperature
7: 72 percent / m-CPBA / tetrahydrofuran / 1 h / Ambient temperature
With
hydrogenchloride; methanol; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; iodine; sodium; iron(III) chloride; lithium carbonate; lithium fluoride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; pentan-1-ol;
DOI:10.1021/jo00331a019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NBS, AIBN; 2.) Li2CO3, LiF; 3.) I2
2: 98 percent / NBS, AIBN / CCl4 / 30 h / 70 - 75 °C
3: 82 percent / Li2CO3, LiF / hexamethylphosphoric acid triamide / 6 h / 90 - 95 °C
4: 85 percent / NH3(gas)/MeOH / methanol; tetrahydrofuran / 2 h / Ambient temperature
5: 72 percent / m-CPBA / tetrahydrofuran / 1 h / Ambient temperature
With
methanol; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; iodine; lithium carbonate; lithium fluoride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00331a019