3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

Base Information

Chemical Name:3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
CAS No.:886047-22-9
Molecular Formula:C₁₉H₂₄ClN₅O₃S
Molecular Weight:437.95
Hs Code.:
Mol file:886047-22-9.mol

Synonyms:

Suppliers and Price of 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LY2119620
1mg
$ 100.00

Tocris
LY2119620 ≥98%(HPLC)
10
$ 152.00

Tocris
LY2119620 ≥98%(HPLC)
50
$ 642.00

Medical Isotopes, Inc.
LY2119620
1 mg
$ 595.00

Medical Isotopes, Inc.
LY2119620
25 mg
$ 1025.00

DC Chemicals
LY2119620 >98%
1 g
$ 2600.00

DC Chemicals
LY2119620 >98%
250 mg
$ 1500.00

DC Chemicals
LY2119620 >98%
100 mg
$ 750.00

Crysdot
LY2119620 95+%
10mg
$ 126.00

Crysdot
LY2119620 95+%
25mg
$ 245.00

Total 12 raw suppliers

Chemical Property of 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

Chemical Property:

Boiling Point:692.4±55.0 °C(Predicted)
PKA:12.90±0.20(Predicted)
Density:1.46±0.1 g/cm3(Predicted)
Solubility.:≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

99%, ^*data from raw suppliers

LY2119620 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 μM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh; ) and the mAChR agonists iperoxo and oxotremorine M at human recombinant M2 and M4 receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response).
Uses LY 2119620 acts as a novel positive allosteric modulator in the treatment of schizophrenia acting as an anti-psychotic agent.

Technology Process of 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

There total 1 articles about 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 109-01-3
1-methyl-piperazine

: 886047-57-0
(3-amino-5-chloro-2-cyclopropylcarbamoyl-4-methyl-thieno[2,3-b]pyridin-6-yloxy)-acetic acid

: 886047-22-9
LY2119620

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 50 ℃; for 48h;