1-(Cyclopropylcarbonyl)indolin-5-amine

Base Information

• Chemical Name: 1-(Cyclopropylcarbonyl)indolin-5-amine
• CAS No.: 927996-72-3
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.256
• Mol file: 927996-72-3.mol

Synonyms:

Chemical Property of 1-(Cyclopropylcarbonyl)indolin-5-amine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(5-Amino-2,3-dihydro-indol-1-yl)-cyclopropyl-methanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-(Cyclopropylcarbonyl)indolin-5-amine

There total 2 articles about 1-(Cyclopropylcarbonyl)indolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cyclopropyl (5-nitro-1H-indol-1-yl)methanone → (5-aminoindolin-1-yl)(cyclopropyl)methanone (927996-72-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 50 - 60 ℃; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.5b00805

Reference yield:

5-nitroindole (6146-52-7) → (5-aminoindolin-1-yl)(cyclopropyl)methanone (927996-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 50 - 60 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.jmedchem.5b00805

Reference yield:

(5-aminoindolin-1-yl)(cyclopropyl)methanone (927996-72-3) → 3-(cyclopropylmethanone)-2,3-dihydro-7-phenyl-1H-pyrrolo[3,2-f]quinolin-9(6H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; calcium sulfate / ethanol / Reflux

2: diphenylether / 250 °C

With calcium sulfate; acetic acid; In diphenylether; ethanol;

DOI:10.1021/acs.jmedchem.5b00805

upstream raw materials:

5-nitroindole

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