1,2,3,4,5,6-hexafluoro-naphthalene

Base Information

Chemical Name:1,2,3,4,5,6-hexafluoro-naphthalene
CAS No.:68395-57-3
Molecular Formula:C₁₀H₂F₆
Molecular Weight:236.116
Hs Code.:

Synonyms:

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Chemical Property of 1,2,3,4,5,6-hexafluoro-naphthalene

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Technology Process of 1,2,3,4,5,6-hexafluoro-naphthalene

There total 1 articles about 1,2,3,4,5,6-hexafluoro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73501-11-8
β-perfluoronaphthyllithium

: 68395-57-3
1,2,3,4,5,6-hexafluoro-naphthalene

: 7789-24-4
lithium fluoride

Guidance literature:: warming from -78 to 20°C;
DOI:10.1039/c39790001147

Reference yield:

: 68395-57-3
1,2,3,4,5,6-hexafluoro-naphthalene

: (R)-4,4’,5,5’,6,6’,7,7’,8,8’-decafluoro-3,3’-diphenyl-1,1’-bi-2-naphthol

Guidance literature:: Multi-step reaction with 7 steps

1.1: bis(2,2,6,6-tetramethylpiperidyl)magnesium-bis(lithium chloride) / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 0.5 h / Inert atmosphere

2.1: potassium bromide; bromine / water; tetrahydrofuran / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / Inert atmosphere

4.1: copper / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

5.1: boron tribromide / dichloromethane / 12 h / 40 °C / Inert atmosphere

6.1: N-benzylcinchonidinium chloride / acetonitrile / 18 h / 0 - 80 °C / Resolution of racemate; Inert atmosphere

7.1: (bis(tricyclohexyl)phosphine)palladium(II) dichloride / tetrahydrofuran / 36 h / -78 - 60 °C / Inert atmosphere

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; N-benzylcinchonidinium chloride; bromine; boron tribromide; copper; potassium carbonate; potassium bromide; bis(2,2,6,6-tetramethylpiperidyl)magnesium-bis(lithium chloride); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chir.22429

Reference yield:

: 68395-57-3
1,2,3,4,5,6-hexafluoro-naphthalene

: C₃₂H₁₁F₁₀O₄P

Guidance literature:: Multi-step reaction with 8 steps

1.1: bis(2,2,6,6-tetramethylpiperidyl)magnesium-bis(lithium chloride) / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 0.5 h / Inert atmosphere

2.1: potassium bromide; bromine / water; tetrahydrofuran / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / Inert atmosphere

4.1: copper / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

5.1: boron tribromide / dichloromethane / 12 h / 40 °C / Inert atmosphere

6.1: N-benzylcinchonidinium chloride / acetonitrile / 18 h / 0 - 80 °C / Resolution of racemate; Inert atmosphere

7.1: (bis(tricyclohexyl)phosphine)palladium(II) dichloride / tetrahydrofuran / 36 h / -78 - 60 °C / Inert atmosphere

8.1: pyridine; trichlorophosphate / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; N-benzylcinchonidinium chloride; bromine; boron tribromide; copper; potassium carbonate; potassium bromide; bis(2,2,6,6-tetramethylpiperidyl)magnesium-bis(lithium chloride); trichlorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chir.22429