(R)-2-methyl-1,1-dimethoxydecane

Base Information

• Chemical Name: (R)-2-methyl-1,1-dimethoxydecane
• CAS No.: 1413919-14-8
• Molecular Formula: C₁₃H₂₈O₂
• Molecular Weight: 216.364
• Mol file: 1413919-14-8.mol

Synonyms:

Chemical Property of (R)-2-methyl-1,1-dimethoxydecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-methyl-1,1-dimethoxydecane

There total 3 articles about (R)-2-methyl-1,1-dimethoxydecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-bromo-hexane (111-25-1) + (2R)-4-bromo-1,1-dimethoxy-2-methylbutane (1413919-12-6) → (R)-2-methyl-1,1-dimethoxydecane (1413919-14-8)

Guidance literature:

1-bromo-hexane; With magnesium; In tetrahydrofuran;

(2R)-4-bromo-1,1-dimethoxy-2-methylbutane; With lithium chloride; copper dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

DOI:10.1016/j.tetasy.2012.09.002

Reference yield:

(3R)-4,4-dimethoxy-3-methylbutan-1-ol (107650-07-7) → (R)-2-methyl-1,1-dimethoxydecane (1413919-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / diethyl ether / 1 h / 0 °C

2.1: tetrabutylammomium bromide; triethylamine / acetone / 1.5 h / 55 °C

3.1: magnesium / tetrahydrofuran

3.2: 1 h / 20 °C

With tetrabutylammomium bromide; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; acetone;

DOI:10.1016/j.tetasy.2012.09.002

Reference yield:

methyl (3R)-4,4,4-trimethoxy-3-methylbutanoate (1283688-50-5) → (R)-2-methyl-1,1-dimethoxydecane (1413919-14-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2.1: triethylamine / diethyl ether / 1 h / 0 °C

3.1: tetrabutylammomium bromide; triethylamine / acetone / 1.5 h / 55 °C

4.1: magnesium / tetrahydrofuran

4.2: 1 h / 20 °C

With lithium aluminium tetrahydride; tetrabutylammomium bromide; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; acetone;

DOI:10.1016/j.tetasy.2012.09.002

upstream raw materials:

(3R)-4,4-dimethoxy-3-methylbutan-1-ol

1-bromo-hexane

(2R)-4-bromo-1,1-dimethoxy-2-methylbutane

methyl (3R)-4,4,4-trimethoxy-3-methylbutanoate