Anagrelide Related Compound A (25 mg) (ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate)

Base Information

• Chemical Name: Anagrelide Related Compound A (25 mg) (ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate)
• CAS No.: 85325-12-8
• Molecular Formula: C₁₁H₁₄Cl₂N₂O₂*ClH
• Molecular Weight: 313.611
• Hs Code.: 2933595960
• Mol file: 85325-12-8.mol

Synonyms:

Chemical Property of Anagrelide Related Compound A (25 mg) (ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate)

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl-2-(6-amino-2,3-dichlorobenzylamino)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl-2-(6-amino-2,3-dichlorobenzylamino)acetate Hydrochloride is a compound related to the synthesis and preparation of Anagrelide (A637300), a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic.

Technology Process of Anagrelide Related Compound A (25 mg) (ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate)

There total 2 articles about Anagrelide Related Compound A (25 mg) (ethyl 2-(6-amino-2,3-dichlorobenzylamino)acetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride (70380-50-6) → N-(6-amino-2,3-dichlorobenzyl)glycine ethyl ester dihydrochloride (85325-12-8,882301-57-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; isopropyl alcohol; at 20 ℃; under 225.023 Torr;

Reference yield:

N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride (70380-50-6) → ethyl-N-(2,3-dichloro-6-amino benzyl) glycine HCl (85325-12-8,882301-57-7)

Guidance literature:

With stannous chloride;

Reference yield: 75.0%

N-(6-amino-2,3-dichlorobenzyl)glycine ethyl ester dihydrochloride (85325-12-8,882301-57-7) + bromocyane (506-68-3) → (2-amino-5,6-dichloroquinazolin-3(4H)-yl)acetic acid ethyl ester hydrobromide

Guidance literature:

N-(6-amino-2,3-dichlorobenzyl)glycine ethyl ester dihydrochloride; With sodium ethanolate; In ethanol; at 8 ℃; pH=11.2 - 11.8;

bromocyane; In ethanol; at 8 - 20 ℃; for 18h;

upstream raw materials:

N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride

Refernces

• 1、 -. "Process for the preparation of ethyl-N-(2,3 dichloro-6-nitrobenzyl) glycine". . . Retrieved 2008/06/13.