1-bromo-2-(methoxy-d₃)benzene

Base Information

• Chemical Name: 1-bromo-2-(methoxy-d₃)benzene
• CAS No.: 892397-56-7
• Molecular Formula: C₇H₇BrO
• Molecular Weight: 190.012
• Mol file: 892397-56-7.mol

Synonyms:

Chemical Property of 1-bromo-2-(methoxy-d₃)benzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-2-(methoxy-d₃)benzene

There total 2 articles about 1-bromo-2-(methoxy-d₃)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

iodomethane-d3 (865-50-9) + 2-hydroxybromobenzene (95-56-7) → 1-bromo-2-(methoxy-d3)benzene (892397-56-7)

Guidance literature:

With potassium hydroxide; In acetonitrile; for 3.5h;

DOI:10.1016/j.ejmech.2016.08.068

Reference yield: 89.1%

2-hydroxybromobenzene (95-56-7) + <2H9>trimethylsulphoxonium iodide (23726-00-3) → 1-bromo-2-(methoxy-d3)benzene (892397-56-7)

Guidance literature:

With potassium hydroxide; at 65 ℃; for 18h; Sealed tube;

DOI:10.1021/acs.orglett.8b03641

Reference yield:

1-bromo-2-(methoxy-d3)benzene (892397-56-7) → (S)-2-((6-(2-(methoxy-d3)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; triethylamine / 5 h / 110 °C / Sealed tube; Inert atmosphere

2: potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); potassium carbonate; triethylamine; In 1,4-dioxane; water; 2: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2016.08.068

upstream raw materials:

iodomethane-d3

2-hydroxybromobenzene

<²H9>trimethylsulphoxonium iodide