5-chloro-4-methoxy-2-nitrobenzaldehyde

Base Information

• Chemical Name: 5-chloro-4-methoxy-2-nitrobenzaldehyde
• CAS No.: 75618-42-7
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.593
• Mol file: 75618-42-7.mol

Synonyms:

Chemical Property of 5-chloro-4-methoxy-2-nitrobenzaldehyde

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-4-methoxy-2-nitrobenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-4-methoxy-2-nitrobenzaldehyde

There total 2 articles about 5-chloro-4-methoxy-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(bromomethyl)-5-chloro-4-methoxy-2-nitrobenzene → 5-chloro-4-methoxy-2-nitrobenzaldehyde (75618-42-7)

Guidance literature:

With 4-methylmorpholine N-oxide; In acetonitrile; at 0 - 20 ℃; for 16h; Inert atmosphere; Molecular sieve;

DOI:10.1124/dmd.115.069112

Reference yield:

1-chloro-2-methoxy-5-methyl-4-nitrobenzene (62492-41-5) → 5-chloro-4-methoxy-2-nitrobenzaldehyde (75618-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 48 h / Reflux; Inert atmosphere

2: 4-methylmorpholine N-oxide / acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere; Molecular sieve

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 4-methylmorpholine N-oxide; In ethyl acetate; acetonitrile;

DOI:10.1124/dmd.115.069112

Reference yield:

5-chloro-4-methoxy-2-nitrobenzaldehyde (75618-42-7) → 4-chloro-2-((3S)-7-chloro-6-fluoro-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5-methoxyaniline

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 120 h / 20 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethanol / 3 h / 60 °C / Inert atmosphere

With tin(II) chloride dihdyrate; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1124/dmd.115.069112

upstream raw materials:

1-chloro-2-methoxy-5-methyl-4-nitrobenzene

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