Nintedanib impurity G

Base Information

• Chemical Name: Nintedanib impurity G
• CAS No.: 894783-61-0
• Molecular Formula: C₃₀H₃₁N₅O₄
• Molecular Weight: 525.607
• Mol file: 894783-61-0.mol

Synonyms:

Chemical Property of Nintedanib impurity G

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

DesmethylNintedanib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Desmethyl Nintedanib is an impurity of Intedanib (I666650), which is an antitumor agent. Desmethyl Nintedanib was used in the study of synthesizing indolinones as triple angiokinase inhibitors.

Technology Process of Nintedanib impurity G

There total 2 articles about Nintedanib impurity G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide (262368-25-2) + (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (1168152-07-5) → (Z)-3-({4-[2-(4-methylpiperazin-1-yl)acetylamino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (894783-61-0)

Guidance literature:

N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm900431g

Reference yield:

→ (Z)-3-({4-[2-(4-methylpiperazin-1-yl)acetylamino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (894783-61-0)

Guidance literature:

upstream raw materials:

N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide

(E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester