4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane

Base Information

• Chemical Name: 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane
• CAS No.: 132156-55-9
• Molecular Formula: C₁₈H₃₀O
• Molecular Weight: 262.436
• Mol file: 132156-55-9.mol

Synonyms:

Chemical Property of 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane

There total 4 articles about 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2e,4e-Di-tert-butyladamantane-2a,4a-diol (132156-48-0) → 4-tert-Butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane (132156-55-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1021/jo00005a012

Reference yield: 29.0%

2,4-adamantanedione (19214-00-7) + tert.-butyl lithium (594-19-4) → 2e-tert-butyladamantan-2a,4a-diol (132156-41-3,132203-36-2,132203-39-5) + 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane (132156-55-9) + 2a-tert-butyl-4-oxoadamantan-2e-ol (132156-44-6,132203-41-9) + 2e-tert-butyl-4-oxoadamantan-2a-ol (132156-44-6,132203-41-9)

Guidance literature:

In diethyl ether; pentane; Further byproducts given; Ambient temperature;

DOI:10.1021/jo00005a011

Reference yield:

4e-Hydroxytricyclo<3.3.1.13,7>decan-2-on (26278-43-3,27863-77-0,27863-78-1,51020-64-5,51020-65-6,103419-82-5,103419-83-6) → 4-tert-butyl-2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane (132156-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Jones oxidation

2: 2 percent / diethyl ether; pentane / Ambient temperature

In diethyl ether; pentane;

DOI:10.1021/jo00005a011

upstream raw materials:

2^e,4^e-Di-tert-butyladamantane-2^a,4^a-diol

2,4-adamantanedione

tert.-butyl lithium

4^e-Hydroxytricyclo<3.3.1.1^3,7>decan-2-on