Technology Process of 1,17-Bis(tetrahydro-2H-pyran-2-yloxy)-5,8-heptadecadiyne
There total 4 articles about 1,17-Bis(tetrahydro-2H-pyran-2-yloxy)-5,8-heptadecadiyne which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / I2, imidazole, Ph3P / diethyl ether; acetonitrile
2: 91 percent / dimethylsulfoxide; pentane / 6 h / Ambient temperature
3: 1.) EtMgBr, CuBr*Me2S / 1.) THF, ether, 2.) THF
With
1H-imidazole; copper(I) bromide dimethylsulfide complex; ethylmagnesium bromide; iodine; triphenylphosphine;
In
diethyl ether; dimethyl sulfoxide; acetonitrile; pentane;
DOI:10.1021/jo00106a037
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 72 percent / I2, imidazole, Ph3P / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) r.t., 1 h
2: 1.) EtMgBr, CuBr*Me2S / 1.) THF, ether, 2.) THF
With
1H-imidazole; copper(I) bromide dimethylsulfide complex; ethylmagnesium bromide; iodine; triphenylphosphine;
In
dichloromethane;
DOI:10.1021/jo00106a037
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / dimethylsulfoxide; pentane / 6 h / Ambient temperature
2: 1.) EtMgBr, CuBr*Me2S / 1.) THF, ether, 2.) THF
With
copper(I) bromide dimethylsulfide complex; ethylmagnesium bromide;
In
dimethyl sulfoxide; pentane;
DOI:10.1021/jo00106a037