C₃₀H₄₃N₃O₇

Base Information

• Chemical Name: C₃₀H₄₃N₃O₇
• CAS No.: 1332832-22-0
• Molecular Formula: C₃₀H₄₃N₃O₇
• Molecular Weight: 557.687
• Mol file: 1332832-22-0.mol

Synonyms:

Chemical Property of C₃₀H₄₃N₃O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₄₃N₃O₇

There total 7 articles about C₃₀H₄₃N₃O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-benzyl 2-methyl (2S,4R)-4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate (1269195-05-2) + C12H23N*C15H27NO4 (1184176-88-2) → methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate (923591-06-4) + C30H43N3O7 (1332832-22-0)

Guidance literature:

1-benzyl 2-methyl (2S,4R)-4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate; C₁₂H₂₃N*C₁₅H₂₇NO₄; With palladium diacetate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 2h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In 1-methyl-pyrrolidin-2-one; under 2828.7 Torr;

With 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo2011494

Reference yield:

4-bromo-2,3-dihydro-1H-isoindole hydrochloride (923590-95-8) → methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate (923591-06-4) + C30H43N3O7 (1332832-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1 h / 65 - 70 °C

1.2: 6 h / 65 - 70 °C

2.1: palladium diacetate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere

2.2: 2828.7 Torr

With palladium diacetate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 2.1: Heck reaction;

DOI:10.1021/jo2011494

Reference yield:

4-bromo-N-benzylisoindoline pTSA salt (1170994-04-3) → methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate (923591-06-4) + C30H43N3O7 (1332832-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / chlorobenzene / 0.25 h

1.2: 16 h / 90 - 95 °C

1.3: 4 h / 60 - 65 °C

2.1: N,N-dimethyl-formamide / 1 h / 65 - 70 °C

2.2: 6 h / 65 - 70 °C

3.1: palladium diacetate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere

3.2: 2828.7 Torr

With palladium diacetate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; chlorobenzene; 3.1: Heck reaction;

DOI:10.1021/jo2011494

upstream raw materials:

4-bromo-2,3-dihydro-1H-isoindole hydrochloride

1-benzyl 2-methyl (2S,4R)-4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

C₁₂H₂₃N*C₁₅H₂₇NO₄

4-bromo-N-benzylisoindoline pTSA salt

Refernces