15-fluoro-15-deoxyprostaglandin F2α

Base Information

Chemical Name:15-fluoro-15-deoxyprostaglandin F2α
CAS No.:77340-85-3
Molecular Formula:C₂₀H₃₃FO₄
Molecular Weight:356.478
Hs Code.:

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Suppliers and Price of 15-fluoro-15-deoxyprostaglandin F2α

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 15-fluoro-15-deoxyprostaglandin F2α

Chemical Property:

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Technology Process of 15-fluoro-15-deoxyprostaglandin F2α

There total 5 articles about 15-fluoro-15-deoxyprostaglandin F2α which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 74017-28-0
15-fluoro-15-deoxyprostaglandin F2α methyl ester

: 77340-85-3,77220-88-3
15-fluoro-15-deoxyprostaglandin F2α

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 2h;
DOI:10.1007/s10600-012-0224-2

Reference yield:

: 33854-16-9
(+)-prostaglandin F_2α

: 77340-85-3,77220-88-3
15-fluoro-15-deoxyprostaglandin F2α

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-diethyl-1,1,1-trimethylsilanamine / acetone / 0.67 h / -40 °C

1.2: 18 h / 23 °C

1.3: 2 h / 40 °C

2.1: morpholinosulfur trifluoride / dichloromethane / -70 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1 h / 40 °C

4.1: potassium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With sodium methylate; morpholinosulfur trifluoride; N,N-diethyl-1,1,1-trimethylsilanamine; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; acetone;
DOI:10.1007/s10600-012-0224-2

Reference yield:

: 71691-37-7
9,11,15-triacetylprostaglandin F2α methyl ester

: 77340-85-3,77220-88-3
15-fluoro-15-deoxyprostaglandin F2α

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 0.5 h / 23 °C

2: morpholinosulfur trifluoride / dichloromethane / -70 °C / Inert atmosphere

3: sodium methylate / methanol / 1 h / 40 °C

4: potassium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With sodium methylate; potassium carbonate; morpholinosulfur trifluoride; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1007/s10600-012-0224-2