2'3'-cGAMP

Base Information

• Chemical Name: 2'3'-cGAMP
• CAS No.: 1441190-66-4
• Molecular Formula: C₂₀H₂₄N₁₀O₁₃P₂
• Molecular Weight: 674.417
• Mol file: 1441190-66-4.mol

Synonyms:

Chemical Property of 2'3'-cGAMP

Chemical Property:

• Boiling Point: 1159.9±75.0 °C(Predicted)
• PKA: 0.89±0.70(Predicted)
• Density: 2.61±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

2'3'-cGAMP >99.5% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: 2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1?Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3?Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4?DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5
• Uses: 2′,3′-cGAMP sodium salt has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.

Technology Process of 2'3'-cGAMP

There total 1 articles about 2'3'-cGAMP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

guanosine-5'-triphosphate + ATP (56-65-5,896506-78-8) → 2'3'-cGAMP (1441190-66-4) + GMP-2'-GTP + AMP-2'-GTP + diadenosine tetraphosphate (17730-98-2)

Guidance literature:

With cyclic GMP-AMP synthase; interferon stimulatory ds-DNA; sodium chloride; magnesium chloride; In aq. buffer; at 37 ℃; pH=7.5; Concentration; Reagent/catalyst; Kinetics; Enzymatic reaction;

DOI:10.1002/pro.3304

upstream raw materials:

ATP

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