4-[(chloroacetyl)amino]-N-cyclopentylbenzamide

Base Information

Chemical Name:4-[(chloroacetyl)amino]-N-cyclopentylbenzamide
CAS No.:908518-25-2
Molecular Formula:C₁₄H₁₇ClN₂O₂
Molecular Weight:280.754
Hs Code.:
DSSTox Substance ID:DTXSID901237451
Mol file:908518-25-2.mol

Synonyms:4-[(chloroacetyl)amino]-N-cyclopentylbenzamide;908518-25-2;4-(2-chloroacetamido)-N-cyclopentylbenzamide;4-[(2-chloroacetyl)amino]-N-cyclopentylbenzamide;DTXSID901237451;BBL017824;MFCD08593590;STK483409;AKOS003237502;MCULE-1883382730;VS-06523

Suppliers and Price of 4-[(chloroacetyl)amino]-N-cyclopentylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-[(Chloroacetyl)amino]-N-cyclopentylbenzamide
500mg
$ 189.00

Crysdot
4-(2-Chloroacetamido)-N-cyclopentylbenzamide 97%
5g
$ 811.00

Total 2 raw suppliers

Chemical Property of 4-[(chloroacetyl)amino]-N-cyclopentylbenzamide

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:280.0978555
Heavy Atom Count:19
Complexity:321

Purity/Quality:

98%min ^*data from raw suppliers

4-[(Chloroacetyl)amino]-N-cyclopentylbenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:

Useful:

Canonical SMILES:C1CCC(C1)NC(=O)C2=CC=C(C=C2)NC(=O)CCl

Technology Process of 4-[(chloroacetyl)amino]-N-cyclopentylbenzamide

There total 3 articles about 4-[(chloroacetyl)amino]-N-cyclopentylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 74233-61-7
4-(2-chloroacetamido)benzoyl chloride

: 1003-03-8
Cyclopentamine

: 908518-25-2
4-(2-chloroacetamido)-N-cyclopentylbenzamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 8h;
DOI:10.1080/14756366.2021.1915303

Reference yield:

: 4596-39-8
4-(2-chloroacetamido)benzoic acid

: 908518-25-2
4-(2-chloroacetamido)-N-cyclopentylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4 h / Reflux

2: triethylamine / acetonitrile / 8 h / 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1080/14756366.2021.1915303

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 908518-25-2
4-(2-chloroacetamido)-N-cyclopentylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4 h / Reflux

3: triethylamine / acetonitrile / 8 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/14756366.2021.1915303