4-Chloro-4'-(dimethylamino)benzhydrol

Base Information

• Chemical Name: 4-Chloro-4'-(dimethylamino)benzhydrol
• CAS No.: 844683-40-5
• Molecular Formula: C₁₅H₁₆ClNO
• Molecular Weight: 261.751
• DSSTox Substance ID: DTXSID201222130
• Nikkaji Number: J3.365.142B
• Mol file: 844683-40-5.mol

Synonyms:4-Chloro-4'-(dimethylamino)benzhydrol;844683-40-5;(4-Chlorophenyl)(4-(dimethylamino)phenyl)methanol;(4-Chlorophenyl)[4-(dimethylamino)phenyl]methanol;DTXSID201222130;AKOS013209122;4-Chloro-alpha-[4-(dimethylamino)phenyl]benzenemethanol

Chemical Property of 4-Chloro-4'-(dimethylamino)benzhydrol

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 261.0920418
• Heavy Atom Count: 18
• Complexity: 243

Purity/Quality:

4-CHLORO-4'-(DIMETHYLAMINO)BENZHYDROL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)O

Technology Process of 4-Chloro-4'-(dimethylamino)benzhydrol

There total 2 articles about 4-Chloro-4'-(dimethylamino)benzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-chlorophenyltrimethylsilane (10557-71-8) + 4-dimethylamino-benzaldehyde (100-10-7) → (4-chlorophenyl)(4-(dimethylamino)phenyl)methanol (844683-40-5)

Guidance literature:

4-chlorophenyltrimethylsilane; 4-dimethylamino-benzaldehyde; With potassium trimethylsilonate; tetrabutyl-ammonium chloride; In tetrahydrofuran; at 0 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In water; for 0.5h;

DOI:10.1021/jo5007637

Reference yield:

4-chlorophenylmagnesium iodide (7270-47-5) + 4-dimethylamino-benzaldehyde (100-10-7) → (4-chlorophenyl)(4-(dimethylamino)phenyl)methanol (844683-40-5)

Guidance literature:

With diethyl ether;

upstream raw materials:

4-chlorophenylmagnesium iodide

4-dimethylamino-benzaldehyde

4-chlorophenyltrimethylsilane

Refernces