XL 228

Base Information

Chemical Name:XL 228
CAS No.:898280-07-4
Molecular Formula:C₂₂H₃₁N₉O
Molecular Weight:437.548
Hs Code.:
Mol file:898280-07-4.mol

Synonyms:

Suppliers and Price of XL 228

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
XL228
100mg
$ 625.00

DC Chemicals
XL-228 >98%
100 mg
$ 450.00

DC Chemicals
XL-228 >98%
1 g
$ 1800.00

Crysdot
XL228 98+%
100mg
$ 488.00

Crysdot
XL228 98+%
50mg
$ 326.00

Crysdot
XL228 98+%
10mg
$ 117.00

Crysdot
XL228 98+%
5mg
$ 85.00

ChemScene
XL228 99.61%
10mg
$ 216.00

ChemScene
XL228 99.61%
5mg
$ 156.00

ChemScene
XL228 99.61%
100mg
$ 900.00

Total 15 raw suppliers

Chemical Property of XL 228

Chemical Property:

Solubility.:≥21.9 mg/mL in DMSO; insoluble in H2O; ≥27.6 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

XL228 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses XL228 is a multi-targeted protein kinase inhibitor in patients with solid tumors or multiple myeloma. It is a COVID19-related research product.

Technology Process of XL 228

There total 6 articles about XL 228 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 109-01-3
1-methyl-piperazine

: 1449314-09-3
N-(4-chloro-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)-N-((3-isopropylisoxazol-5-yl)methyl)acetamide

: 898280-07-4
XL228

Guidance literature:: 1-methyl-piperazine; N-(4-chloro-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)-N-((3-isopropylisoxazol-5-yl)methyl)acetamide; In Isopropyl acetate; at 88 - 90 ℃; for 4.5h; Large scale;

With potassium carbonate; In methanol; at 20 ℃; for 12h; Temperature; Time; Solvent; Large scale;
DOI:10.1021/op400137m

Reference yield: 69.0%

: 109-01-3
1-methyl-piperazine

: 898281-49-7
6-chloro-N₄-(5-cyclopropyl-2H-pyrazol-3-yl)-N₂-(3-isopropylisoxazol-5-ylmethyl)pyrimidine-2,4-diamine

: 898280-07-4
N4-(5-Cyclopropyl-2H-pyrazol-3-yl)-N2-(3-isopropyl-isoxazol-5-ylmethyl)-6-(4-methyl-piperazin-1-yl)-pyrimidine-2,4-diamine

Guidance literature:: at 110 ℃; for 3h;

Reference yield:

: 1449314-07-1
N-(4,6-dichloropyrimidin-2-yl)-N-(prop-2-ynyl)acetamide

: 898280-07-4
XL228

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl acetamide / 10 h / 40 °C / Large scale

2.1: triethylamine / N,N-dimethyl acetamide / 12 h / 80 °C

3.1: Isopropyl acetate / 4.5 h / 88 - 90 °C / Large scale

3.2: 12 h / 20 °C / Large scale

With triethylamine; In N,N-dimethyl acetamide; Isopropyl acetate;
DOI:10.1021/op400137m