ajugamarin chlorohydrin

Base Information

• Chemical Name: ajugamarin chlorohydrin
• CAS No.: 85447-27-4
• Molecular Formula: C₂₉H₄₁ClO₁₀
• Molecular Weight: 585.092
• Mol file: 85447-27-4.mol

Synonyms:

Chemical Property of ajugamarin chlorohydrin

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Ajugamarinchlorohydrin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ajugamarin chlorohydrin

There total 3 articles about ajugamarin chlorohydrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ajugamarin A1 (78798-40-0) → (E)-2-Methyl-but-2-enoic acid (1R,4R,4aR,5S,7R,8S,8aR)-5-acetoxy-4a-acetoxymethyl-4-chloromethyl-4-hydroxy-8-[(S)-2-hydroxy-2-(5-oxo-2,5-dihydro-furan-3-yl)-ethyl]-7,8-dimethyl-decahydro-naphthalen-1-yl ester (85447-27-4)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Yield given; Ambient temperature;

Reference yield:

ajugamarin A1 (78798-40-0) → ajugamarin chlorohydrin (85447-27-4)

Guidance literature:

With hydrogenchloride; In methanol; for 24h; Ambient temperature;

Reference yield:

(E)-2-methylbut-2-enoyl chloride (35660-94-7) + ajugamarin C1 ((12S)-6α,19-diacetoxy-1β,12-dihydroxy-4,18-epoxyneo-clerod-13(14)-en-15,16-olide) (121449-64-7) → (E)-2-Methyl-but-2-enoic acid (1R,4R,4aR,5S,7R,8S,8aR)-5-acetoxy-4a-acetoxymethyl-4-chloromethyl-4-hydroxy-8-[(S)-2-hydroxy-2-(5-oxo-2,5-dihydro-furan-3-yl)-ethyl]-7,8-dimethyl-decahydro-naphthalen-1-yl ester (85447-27-4)

Guidance literature:

With dmap; In dichloromethane; for 32h; Yield given; Ambient temperature;

upstream raw materials:

(E)-2-methylbut-2-enoyl chloride

ajugamarin C1 ((12S)-6α,19-diacetoxy-1β,12-dihydroxy-4,18-epoxyneo-clerod-13(14)-en-15,16-olide)

ajugamarin A1

ajugamarin A₁

Refernces

• 1、 Shimomura, Hiroko,Sashida, Yutaka,Ogawa, Kazunori,Iitaka, Yoichi. "The Chemical Constituents of Ajuga Plants. I. neo-Clerodanes from the Leaves of Ajuga nipponensis Makino". . p. 2192 - 2199. Retrieved 2007/10/02.