Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate

Base Information

Chemical Name:Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate
CAS No.:140200-92-6
Molecular Formula:C12H14N2O2
Molecular Weight:218.255
Hs Code.:
DSSTox Substance ID:DTXSID50577636
Nikkaji Number:J452.574D
Wikidata:Q82467703
Mol file:140200-92-6.mol

Synonyms:DTXSID50577636;Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate

Suppliers and Price of Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:218.105527694
Heavy Atom Count:16
Complexity:260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C=CCN(N1)C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate

There total 4 articles about Benzyl 3,6-dihydropyridazine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 706808-63-1
3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 140200-92-6
3,6-Dihydro-2H-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2004.03.075

Reference yield:

: 57699-88-4
1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

: 140200-92-6
3,6-Dihydro-2H-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH; n-Bu₄NI / dimethylformamide / 25 °C

2: NaH; n-Bu₄NI / dimethylformamide / 25 °C

3: 93 percent / Grubbs' catalyst / CH₂Cl₂ / 8 h / 45 °C

4: 96 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.03.075

Reference yield:

: 192725-91-0
N⁽¹⁾-t-butyloxycarbonyl-N⁽²⁾-formylmethyl-N⁽²⁾-benzyloxycarbonyl hydrazine

: 140200-92-6
3,6-Dihydro-2H-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH; n-Bu₄NI / dimethylformamide / 25 °C

2: 93 percent / Grubbs' catalyst / CH₂Cl₂ / 8 h / 45 °C

3: 96 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.03.075