Indotecan

Base Information

• Chemical Name: Indotecan
• CAS No.: 915303-09-2
• Molecular Formula: C₂₆H₂₆N₂O₇
• Molecular Weight: 478.502
• European Community (EC) Number: 967-286-5
• UNII: BTA69L5M8D
• ChEMBL ID: CHEMBL216462
• DSSTox Substance ID: DTXSID90238613
• NCI Thesaurus Code: C95907
• Nikkaji Number: J3.122.179J
• NSC Number: 724998
• Wikidata: Q27274872

Synonyms:indotecan;LMP-400;LMP400;NSC 724998;NSC-724998;NSC724998

Chemical Property of Indotecan

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 478.17400117
• Heavy Atom Count: 35
• Complexity: 872

Purity/Quality:

99%, ^*data from raw suppliers

Indotecan(LMP400) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
• Recent ClinicalTrials: A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas

Technology Process of Indotecan

There total 19 articles about Indotecan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(3-Aminopropyl)morpholine (123-00-2) + 2,3-dimethoxy-8,9-methylenedioxyindeno[1,2-e]-benzopyran-6,11-dione → 2,3-dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4′,5′:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione (915303-09-2)

Guidance literature:

In chloroform; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/jm401814y

Reference yield: 72.0%

morpholine (110-91-8,99108-56-2) + 6-(3-bromo-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (308246-43-7) → 2,3-dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4′,5′:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione (915303-09-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1021/jm060564z

Reference yield: 72.0%

→ 2,3-dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4′,5′:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione (915303-09-2)

Guidance literature:

upstream raw materials:

morpholine

6-(3-bromo-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline

4-(3-Aminopropyl)morpholine

Veratric acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 915303-09-2 2,3-dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4′,5′:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

Send

Send

Metric Ton KG G Pound L ML

Send

Send