BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-

Base Information

Chemical Name:BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-
CAS No.:892414-55-0
Molecular Formula:C₂₀H₂₁ClF₅N₃O₂Si
Molecular Weight:493.936
Hs Code.:
Mol file:892414-55-0.mol

Synonyms:

Suppliers and Price of BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemenu
4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline 95%+
100mg
$ 2535.00

Total 6 raw suppliers

Chemical Property of BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline 95%+ ^*data from reagent suppliers

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Technology Process of BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-

There total 9 articles about BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 892414-51-6
6-chloro-4-nitro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

: 126058-97-7
2,6-di-fluoro-4-aminophenol

: 892414-55-0
4-[(6-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]-pyridin-4-yl)oxy]-3,5-difluoroaniline

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 3h;
DOI:10.1055/s-2006-958935

Reference yield:

: 932406-33-2
2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethane-1,1-diol

: 892414-55-0
4-[(6-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]-pyridin-4-yl)oxy]-3,5-difluoroaniline

Guidance literature:: Multi-step reaction with 8 steps

1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C

2: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

3: 83 percent / thionyl chloride; pyridine / CH₂Cl₂ / 20 °C

4: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C

5: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C

6: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C

7: 65 percent / sodium hydride / dimethylformamide; various solvent(s) / 0.75 h / 20 °C

8: 78 percent / potassium carbonate / dimethylsulfoxide / 3 h / 120 °C

With pyridine; thionyl chloride; hydrogen; nitric acid; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; nickel; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid; 1: Henry reaction;
DOI:10.1055/s-2006-958935

Reference yield:

: 892414-45-8
1,1,1-trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol

: 892414-55-0
4-[(6-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]-pyridin-4-yl)oxy]-3,5-difluoroaniline

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

2: 83 percent / thionyl chloride; pyridine / CH₂Cl₂ / 20 °C

3: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C

4: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C

5: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C

6: 65 percent / sodium hydride / dimethylformamide; various solvent(s) / 0.75 h / 20 °C

7: 78 percent / potassium carbonate / dimethylsulfoxide / 3 h / 120 °C

With pyridine; thionyl chloride; hydrogen; nitric acid; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; nickel; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1055/s-2006-958935