Chemical Property of Pemafibrate
Chemical Property:
- Melting Point:98-99 °C(Solv: ethyl acetate (141-78-6); heptane (142-82-5))
- Boiling Point:676.7±65.0 °C(Predicted)
- PKA:3.23±0.10(Predicted)
- Density:1.250±0.06 g/cm3(Predicted)
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- XLogP3:6.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:13
- Exact Mass:490.21038668
- Heavy Atom Count:36
- Complexity:658
- Purity/Quality:
-
98% *data from raw suppliers
Pemafibrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CCC(C(=O)O)OC1=CC=CC(=C1)CN(CCCOC2=CC=C(C=C2)OC)C3=NC4=CC=CC=C4O3
- Isomeric SMILES:CC[C@H](C(=O)O)OC1=CC=CC(=C1)CN(CCCOC2=CC=C(C=C2)OC)C3=NC4=CC=CC=C4O3
- Recent ClinicalTrials:Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)
- Recent EU Clinical Trials:A Phase 2, Multicenter, Placebo-Controlled, Randomized, Double-Blind, 48-Week Study to Evaluate the Efficacy and Safety of Combination Therapy of K-877-ER and CSG452 in Patients with Noncirrhotic Nonalcoholic Steatohepatitis (NASH) with Liver Fibrosis
- Recent NIPH Clinical Trials:A single-arm study of the efficacy of pemafibrate in patients with NAFLD (non-alcoholic fatty liver disease) complicated by dyslipidemia
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Uses
Pemafibrate is used in the treatment of hyperlipidemia. It also functions as a promising selective PPAR-α modulator for treatment of combined dyslipidemia phase 2 clinical trials with K-877.
