pestalotiopin A tert-butyl ester

Base Information

Chemical Name:pestalotiopin A tert-butyl ester
CAS No.:54493-39-9
Molecular Formula:C₁₂H₂₀O₄
Molecular Weight:228.288
Hs Code.:

Synonyms:

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Chemical Property of pestalotiopin A tert-butyl ester

Chemical Property:

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Technology Process of pestalotiopin A tert-butyl ester

There total 6 articles about pestalotiopin A tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: trans-anhydromevalonic acid tert-butyl ester

: 108-24-7
acetic anhydride

: 54493-39-9,77611-53-1
pestalotiopin A tert-butyl ester

Guidance literature:: With pyridine; dmap; at 20 ℃; for 2h;
DOI:10.1021/acs.jnatprod.1c01176

Reference yield:

: tert-butyl 3-oxo-5-((triisopropylsilyl)oxy)pentanoate

: 54493-39-9,77611-53-1
pestalotiopin A tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere

2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C / Inert atmosphere

3: N,N,N-tributylbutan-1-aminium fluoride; acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

4: dmap; pyridine / 2 h / 20 °C

With pyridine; dmap; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); N,N,N,N,-tetramethylethylenediamine; N,N,N-tributylbutan-1-aminium fluoride; acetic acid; lithium chloride; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/acs.jnatprod.1c01176

Reference yield:

: 35059-50-8
t-butyl diazoacetate

: 54493-39-9,77611-53-1
pestalotiopin A tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: stannous chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere

3: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C / Inert atmosphere

4: N,N,N-tributylbutan-1-aminium fluoride; acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

5: dmap; pyridine / 2 h / 20 °C

With pyridine; dmap; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); N,N,N,N,-tetramethylethylenediamine; N,N,N-tributylbutan-1-aminium fluoride; acetic acid; lithium chloride; stannous chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/acs.jnatprod.1c01176