Technology Process of isoquadrone
There total 10 articles about isoquadrone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) lithium diisopropylamide / 1.) THF, -23 deg C, 1.25 h, 2.) 5 min
2: hydrogen / 5percent Pd-C / methanol / 1 h / Ambient temperature
3: 4.8 mg / tosyl acid hydrate / benzene / 1 h / Heating
With
hydrogen; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
methanol; benzene;
DOI:10.1021/ja00404a026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethyl acetate / 3 h / Ambient temperature
2: 1.00 g / 30percent H2O2, pyridine / CH2Cl2 / 0.75 h / Ambient temperature
3: 1.) lithium diisopropylamide / 1.) THF, -23 deg C, 1.25 h, 2.) 5 min
4: hydrogen / 5percent Pd-C / methanol / 1 h / Ambient temperature
5: 4.8 mg / tosyl acid hydrate / benzene / 1 h / Heating
With
pyridine; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/ja00404a026
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / aq. KOH / methanol / 1.5 h / Heating
2: ethyl acetate / 3 h / Ambient temperature
3: 1.00 g / 30percent H2O2, pyridine / CH2Cl2 / 0.75 h / Ambient temperature
4: 1.) lithium diisopropylamide / 1.) THF, -23 deg C, 1.25 h, 2.) 5 min
5: hydrogen / 5percent Pd-C / methanol / 1 h / Ambient temperature
6: 4.8 mg / tosyl acid hydrate / benzene / 1 h / Heating
With
pyridine; potassium hydroxide; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/ja00404a026
