O-[4-(trifluoromethyl)phenyl]hydroxylamine

Base Information

• Chemical Name: O-[4-(trifluoromethyl)phenyl]hydroxylamine
• CAS No.: 92381-17-4
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.126
• European Community (EC) Number: 856-982-3
• Nikkaji Number: J2.878.168G
• Mol file: 92381-17-4.mol

Synonyms:O-[4-(trifluoromethyl)phenyl]hydroxylamine;92381-17-4;O-(4-(Trifluoromethyl)phenyl)hydroxylamine;4-(Trifluoromethyl)phenoxyamine;SCHEMBL8087112;YVQRIPAYKQMJME-UHFFFAOYSA-N;MFCD21921073;AKOS017982514;BS-17990;CS-0163363;EN300-209606

Chemical Property of O-[4-(trifluoromethyl)phenyl]hydroxylamine

Chemical Property:

• Boiling Point: 202.4±40.0 °C(Predicted)
• Density: 1.320±0.06 g/cm3(Predicted)
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 177.04014830
• Heavy Atom Count: 12
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

O-[4-(trifluoromethyl)phenyl]hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(F)(F)F)ON

Technology Process of O-[4-(trifluoromethyl)phenyl]hydroxylamine

There total 4 articles about O-[4-(trifluoromethyl)phenyl]hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(p-trifluoromethyl-N-phenoxy)phthalimide → O-(4-trifluoromethylphenyl)hydroxylamine (92381-17-4)

Guidance literature:

With hydrazine hydrate; In methanol; chloroform; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201507272

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → O-(4-trifluoromethylphenyl)hydroxylamine (92381-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride; pyridine / 1,2-dichloro-ethane / 48 h / 20 °C / Molecular sieve; Inert atmosphere

2: hydrazine hydrate / methanol; chloroform / 20 °C / Inert atmosphere

With pyridine; hydrazine hydrate; copper(l) chloride; In methanol; chloroform; 1,2-dichloro-ethane;

DOI:10.1002/anie.201507272

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) → O-(4-trifluoromethylphenyl)hydroxylamine (92381-17-4)

Guidance literature:

With potassium tert-butylate; mesitylenesulfonylhydroxylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

DOI:10.1016/0223-5234(94)90027-2

upstream raw materials:

4-hydroxybenzotrifluoride

C₂₆H₁₂F₂₀N₂O₄

4-trifluoromethylphenylboronic acid