MALAYAMYCIN A

Base Information

Chemical Name:MALAYAMYCIN A
CAS No.:828914-61-0
Molecular Formula:C₁₃H₁₈N₄O₇
Molecular Weight:342.309
Hs Code.:29419000

Synonyms:

Suppliers and Price of MALAYAMYCIN A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
MALAYAMYCIN A 95.00%
5MG
$ 501.89

Total 1 raw suppliers

Chemical Property of MALAYAMYCIN A

Chemical Property:

PKA:9.36±0.10(Predicted)
Density:1.58±0.1 g/cm3(Predicted)

Purity/Quality:: MALAYAMYCIN A 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of MALAYAMYCIN A

There total 35 articles about MALAYAMYCIN A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 828914-60-9
2,2-Dimethyl-propionic acid (2R,3R,3aR,6S,7R,7aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-methoxy-7-[3-(2,2,2-trichloro-acetyl)-ureido]-hexahydro-furo[3,2-b]pyran-3-yl ester

: 828914-61-0
[(2R,3R,3aS,6S,7R,7aR)-3-hydroxy-2-(2',4'-dioxo-3',4'-dihydro-2H-pyrimidin-1'-yl)-6-methoxy-hexahydrofuro[3,2-b]pyran-7-yl]-urea

Guidance literature:: With water; methylamine; In methanol; for 72h;

Reference yield:

: (3R,4R,5S)-4-Azido-3,5-dihydroxy-tetrahydro-pyran-2-carbonitrile

: 828914-61-0
[(2R,3R,3aS,6S,7R,7aR)-3-hydroxy-2-(2',4'-dioxo-3',4'-dihydro-2H-pyrimidin-1'-yl)-6-methoxy-hexahydrofuro[3,2-b]pyran-7-yl]-urea

Guidance literature:: Multi-step reaction with 17 steps

1.1: sodium hydroxide / methanol; H₂O / 3 h / 45 °C

2.1: 2.72 g / TMSCl / 13 h / 20 °C

3.1: 95 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

4.1: AlMe₃ / CH₂Cl₂; toluene / 0.67 h / 0 °C

4.2: 68 percent / CH₂Cl₂; toluene / 22 h / 0 - 20 °C

5.1: DIBAL-H / toluene; hexane / 2 h / -78 °C

6.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

7.1: BuLi / tetrahydrofuran; hexane / 0.42 h / -10 °C

7.2: 161 mg / tetrahydrofuran; hexane / 0.5 h / -78 °C

8.1: 91 percent / molecular sieves 4 Angstroem; TBAF / tetrahydrofuran / 16 h / 20 °C

9.1: 81 percent / PTSA; Na₂SO₄ / CH₂Cl₂ / 4 h / 20 °C

10.1: 93 percent / NaH / dimethylformamide / 0 °C

11.1: 100 percent / PTSA / methanol / 24 h / 20 °C

12.1: 76 percent / N-bromosuccinimide / CH₂Cl₂ / 0.33 h / 0 °C

13.1: 100 percent / pyridine; 4-(dimethylamino)pyridine / 20 °C

14.1: 62 percent / NIS; trifluoromethanesulfonic acid / CH₂Cl₂ / 4 h / 20 °C

15.1: Me₃P / tetrahydrofuran; toluene / 0.5 h / 20 °C

15.2: water / toluene; tetrahydrofuran / 0.67 h / Heating

16.1: CH₂Cl₂ / 1 h / 20 °C

17.1: methylamine / methanol; H₂O / 72 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; n-butyllithium; chloro-trimethyl-silane; trifluorormethanesulfonic acid; 4 A molecular sieve; tetrabutyl ammonium fluoride; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; sodium sulfate; methylamine; trimethylphosphane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050727b

Reference yield:

: 864941-81-1
(3R,4R,5S)-4-Azido-3,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester

: 828914-61-0
[(2R,3R,3aS,6S,7R,7aR)-3-hydroxy-2-(2',4'-dioxo-3',4'-dihydro-2H-pyrimidin-1'-yl)-6-methoxy-hexahydrofuro[3,2-b]pyran-7-yl]-urea

Guidance literature:: Multi-step reaction with 15 steps

1.1: 95 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

2.1: AlMe₃ / CH₂Cl₂; toluene / 0.67 h / 0 °C

2.2: 68 percent / CH₂Cl₂; toluene / 22 h / 0 - 20 °C

3.1: DIBAL-H / toluene; hexane / 2 h / -78 °C

4.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

5.1: BuLi / tetrahydrofuran; hexane / 0.42 h / -10 °C

5.2: 161 mg / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.1: 91 percent / molecular sieves 4 Angstroem; TBAF / tetrahydrofuran / 16 h / 20 °C

7.1: 81 percent / PTSA; Na₂SO₄ / CH₂Cl₂ / 4 h / 20 °C

8.1: 93 percent / NaH / dimethylformamide / 0 °C

9.1: 100 percent / PTSA / methanol / 24 h / 20 °C

10.1: 76 percent / N-bromosuccinimide / CH₂Cl₂ / 0.33 h / 0 °C

11.1: 100 percent / pyridine; 4-(dimethylamino)pyridine / 20 °C

12.1: 62 percent / NIS; trifluoromethanesulfonic acid / CH₂Cl₂ / 4 h / 20 °C

13.1: Me₃P / tetrahydrofuran; toluene / 0.5 h / 20 °C

13.2: water / toluene; tetrahydrofuran / 0.67 h / Heating

14.1: CH₂Cl₂ / 1 h / 20 °C

15.1: methylamine / methanol; H₂O / 72 h / 20 °C

With pyridine; 1H-imidazole; dmap; N-Bromosuccinimide; N-iodo-succinimide; n-butyllithium; trifluorormethanesulfonic acid; 4 A molecular sieve; tetrabutyl ammonium fluoride; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; sodium sulfate; methylamine; trimethylphosphane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050727b