5-BROMO-2-METHYLTHIOPHENE-3-SULFONYL CHLORIDE

Base Information

• Chemical Name: 5-BROMO-2-METHYLTHIOPHENE-3-SULFONYL CHLORIDE
• CAS No.: 82834-48-8
• Molecular Formula: C₅H₄BrClO₂S₂
• Molecular Weight: 275.575
• Mol file: 82834-48-8.mol

Synonyms:

Chemical Property of 5-BROMO-2-METHYLTHIOPHENE-3-SULFONYL CHLORIDE

Chemical Property:

• Boiling Point: 330.7±42.0 °C(Predicted)
• Density: 1.861±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-methylthiophene-3-sulfonylchloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-BROMO-2-METHYLTHIOPHENE-3-SULFONYL CHLORIDE

There total 1 articles about 5-BROMO-2-METHYLTHIOPHENE-3-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-methyl thiophene (765-58-2) → 5-bromo-2-methylthiophen-3-sulphonyl chloride (82834-48-8)

Guidance literature:

With chlorosulfonic acid; phosphorus pentachloride; at 10 ℃;

DOI:10.1039/P29820000625

Reference yield:

5-bromo-2-methylthiophen-3-sulphonyl chloride (82834-48-8) → 2-bromo-5-methyl-3-nitrothiophene (82834-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / 1 h / 40 °C

2: 1.) mercury(II) acetate, 2.) HCl / 1.) acetic acid, reflux, 2 h, 2.) water

With hydrogenchloride; mercury(II) diacetate; nitric acid;

DOI:10.1039/P29820000625

upstream raw materials:

2-bromo-5-methyl thiophene

Downstream raw materials:

2-bromo-5-methyl-3-nitrothiophene

Refernces

• 1、 Consiglio, Giovanni,Spinelli, Domenico,Gronowitz, Salo,Hoernfeldt, Anna-Britta,Maltesson, Britta,Noto, Renato. "Kinetics of the Reactions of Some 5-Bromo-2-nitro-3-R-thiophens, 3,4-dibromo-2-nitro-5-R-thiophens, 3-Bromo-2-nitro-5-R-thiophens, and 2-Bromo-3-nitro-5-R-thiophens with Nucleophiles in Methanol". . p. 625 - 630. Retrieved 2007/10/02.