Technology Process of (2Z,4E,8Z,10Z)-N-isobutyldodeca-2,4,8,10-tetraenamide
There total 10 articles about (2Z,4E,8Z,10Z)-N-isobutyldodeca-2,4,8,10-tetraenamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-N-iso-butyl-2-oxoethyl phosphonium chloride;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
C10H14O;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
DOI:10.1021/jo200289f
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: ethylmagnesium bromide / tetrahydrofuran / 50 °C
1.2: 20 - 50 °C
2.1: potassium tert-butylate; dimethyl sulfoxide / tetrahydrofuran / -40 °C
3.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - -10 °C
4.2: -78 - 20 °C
5.1: sodium hydride / diethyl ether; mineral oil / 0 °C
5.2: 0 °C
6.1: diisobutylaluminium hydride / diethyl ether / 0 °C
7.1: naphthalene; lithium; zinc(II) chloride / tetrahydrofuran; methanol / 50 °C
8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - -10 °C
8.2: -78 - 20 °C
9.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
9.2: 2 h / 0 °C
With
oxalyl dichloride; naphthalene; ethylmagnesium bromide; potassium tert-butylate; lithium; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; mineral oil;
4.1: Swern oxidation / 4.2: Swern oxidation / 5.1: Horner-Wadsworth-Emmons olefination / 5.2: Horner-Wadsworth-Emmons olefination / 8.1: Swern oxidation / 8.2: Swern oxidation / 9.1: Wittig reaction / 9.2: Wittig reaction;
DOI:10.1021/jo200289f
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium tert-butylate; dimethyl sulfoxide / tetrahydrofuran / -40 °C
2.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - -10 °C
3.2: -78 - 20 °C
4.1: sodium hydride / diethyl ether; mineral oil / 0 °C
4.2: 0 °C
5.1: diisobutylaluminium hydride / diethyl ether / 0 °C
6.1: naphthalene; lithium; zinc(II) chloride / tetrahydrofuran; methanol / 50 °C
7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - -10 °C
7.2: -78 - 20 °C
8.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
8.2: 2 h / 0 °C
With
oxalyl dichloride; naphthalene; potassium tert-butylate; lithium; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; mineral oil;
3.1: Swern oxidation / 3.2: Swern oxidation / 4.1: Horner-Wadsworth-Emmons olefination / 4.2: Horner-Wadsworth-Emmons olefination / 7.1: Swern oxidation / 7.2: Swern oxidation / 8.1: Wittig reaction / 8.2: Wittig reaction;
DOI:10.1021/jo200289f
