CYCLOHEXYL 2-(4-FLUOROPHENYL)ETHYL KETONE

Base Information

• Chemical Name: CYCLOHEXYL 2-(4-FLUOROPHENYL)ETHYL KETONE
• CAS No.: 898768-92-8
• Molecular Formula: C₁₅H₁₉FO
• Molecular Weight: 234.314
• Mol file: 898768-92-8.mol

Synonyms:

Chemical Property of CYCLOHEXYL 2-(4-FLUOROPHENYL)ETHYL KETONE

Chemical Property:

• Vapor Pressure: 0.000145mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

Cyclohexyl2-(4-fluorophenyl)ethylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CYCLOHEXYL 2-(4-FLUOROPHENYL)ETHYL KETONE

There total 2 articles about CYCLOHEXYL 2-(4-FLUOROPHENYL)ETHYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

cyclohexane (110-82-7,25012-93-5) + 1-(3-(4-fluorophenyl)propanoyl)pyrrolidine-2,5-dione → 1-cyclohexyl-3-(4-fluorophenyl)propan-1-one (898768-92-8)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 20 ℃; for 16h; Irradiation; Inert atmosphere;

DOI:10.1002/anie.202004441

Reference yield:

3-(4-fluorophenyl)propanoyl chloride (772-70-3) → 1-cyclohexyl-3-(4-fluorophenyl)propan-1-one (898768-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium carbonate; (1,2-dimethoxyethane)dichloronickel(II) / benzene / 16 h / 20 °C / Irradiation; Inert atmosphere

With dmap; (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; potassium carbonate; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; benzene;

DOI:10.1002/anie.202004441

upstream raw materials:

cyclohexane

3-(4-fluorophenyl)propanoyl chloride

Refernces