N-DesMethyl IoMeprol Pentaacetate

Base Information

• Chemical Name: N-DesMethyl IoMeprol Pentaacetate
• CAS No.: 87785-51-1
• Molecular Formula: C₂₆H₃₀I₃N₃O₁₃
• Molecular Weight: 973.25
• Mol file: 87785-51-1.mol

Synonyms:

Chemical Property of N-DesMethyl IoMeprol Pentaacetate

Chemical Property:

• Melting Point: >90°C
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

N-DesmethylIomeprolPentaacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Desmethyl Iomeprol Pentaacetate is an intermediate used in the preparation of Iomeprol (I730500), and x-ray contrast agent.

Technology Process of N-DesMethyl IoMeprol Pentaacetate

There total 4 articles about N-DesMethyl IoMeprol Pentaacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide (76801-94-0) + Acetoxyacetyl chloride (13831-31-7) → 5-(acetoxyacetylamino)-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide (87785-51-1)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; for 4h;

Reference yield:

5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide (76801-94-0) → 5-(acetoxyacetylamino)-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide (87785-51-1)

Guidance literature:

In water;

Reference yield:

5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (76801-93-9) → 5-(acetoxyacetylamino)-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide (87785-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / ethyl acetate / 2 h / Reflux

2: N,N-dimethyl-formamide / 4 h / 40 °C

With dmap; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide

5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

Acetoxyacetyl chloride