8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

Base Information

Chemical Name:8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine
CAS No.:939759-08-7
Molecular Formula:C₉H₈F₃NO
Molecular Weight:203.164
Hs Code.:
DSSTox Substance ID:DTXSID00585701
Wikidata:Q82477688
Mol file:939759-08-7.mol

Synonyms:939759-08-7;8-(TRIFLUOROMETHYL)-3,4-DIHYDRO-2H-1,4-BENZOXAZINE;8-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE;8-(TRIFLUOROMETHYL)-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE;DTXSID00585701;GFPMHIXFAJFZCJ-UHFFFAOYSA-N;MB06355;EN300-267690;G74376;3,4-DIHYDRO-8-(TRIFLUOROMETHYL)-2H-1,4-BENZOXAZINE

Suppliers and Price of 8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
8-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine
100mg
$ 330.00

American Custom Chemicals Corporation
8-(TRIFLUOROMETHYL)-3,4-DIHYDRO-2H-1,4-BENZOXAZINE 95.00%
5MG
$ 502.14

AK Scientific
8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine
1g
$ 985.00

AK Scientific
8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine
100mg
$ 407.00

Total 2 raw suppliers

Chemical Property of 8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:203.05579836
Heavy Atom Count:14
Complexity:207

Purity/Quality:

99%+ ^*data from raw suppliers

8-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC2=C(C=CC=C2N1)C(F)(F)F

Technology Process of 8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

There total 3 articles about 8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.64%

: 8-(trifluoromethyl)-2H-benzo[b][1,4]oxaazine-3(4H)-one

: 939759-08-7
8-(trifluoromethyl)-3,4-dihydro-2H-benzo[b][1,4]oxaazine

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1548-62-5
2-Nitro-6-(trifluoromethyl)phenol

: 939759-08-7
8-(trifluoromethyl)-3,4-dihydro-2H-benzo[b][1,4]oxaazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

2: dichloromethane / 2 h / 0 °C

3: borane-THF / tetrahydrofuran / 20 °C

With borane-THF; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 72534-45-3
3-trifluoromethyl-2-hydroxyaniline

: 939759-08-7
8-(trifluoromethyl)-3,4-dihydro-2H-benzo[b][1,4]oxaazine

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 0 °C

2: borane-THF / tetrahydrofuran / 20 °C

With borane-THF; In tetrahydrofuran; dichloromethane;