Technology Process of acetyl narbonolide
There total 12 articles about acetyl narbonolide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
glucose-6-phosphate dehydrogenase; nicotinamide adenine dinucleotide phosphate;
In
aq. phosphate buffer; glycerol;
pH=7.2;
Enzymatic reaction;
DOI:10.1021/ja404134f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h
2.1: n-butyllithium / dimethyl sulfoxide / 1 h / 0 - 110 °C
2.2: 1 h / -78 - 20 °C
3.1: Hoveyda-Grubbs catalyst second generation / 12 h / 50 °C / Inert atmosphere
4.1: hydrogen fluoride / acetonitrile
5.1: tributylphosphine / dichloromethane / 0 °C
6.1: nicotinamide adenine dinucleotide phosphate; glucose-6-phosphate dehydrogenase / aq. phosphate buffer; glycerol / pH 7.2 / Enzymatic reaction
With
n-butyllithium; Hoveyda-Grubbs catalyst second generation; glucose-6-phosphate dehydrogenase; tributylphosphine; hydrogen fluoride; nicotinamide adenine dinucleotide phosphate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
aq. phosphate buffer; dichloromethane; dimethyl sulfoxide; glycerol; acetonitrile;
DOI:10.1021/ja404134f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Hoveyda-Grubbs catalyst second generation / 12 h / 50 °C / Inert atmosphere
2: hydrogen fluoride / acetonitrile
3: tributylphosphine / dichloromethane / 0 °C
4: nicotinamide adenine dinucleotide phosphate; glucose-6-phosphate dehydrogenase / aq. phosphate buffer; glycerol / pH 7.2 / Enzymatic reaction
With
Hoveyda-Grubbs catalyst second generation; glucose-6-phosphate dehydrogenase; tributylphosphine; hydrogen fluoride; nicotinamide adenine dinucleotide phosphate;
In
aq. phosphate buffer; dichloromethane; glycerol; acetonitrile;
DOI:10.1021/ja404134f
