N-(4-{2-[5-Hydroxy-2-(4-Methoxy-benzylcarbaMoyl)-4-oxo-4H-chroMen-7-yloxy]-ethyl}-2-Methoxy-phenyl)-oxalaMic acid

Base Information

• Chemical Name: N-(4-{2-[5-Hydroxy-2-(4-Methoxy-benzylcarbaMoyl)-4-oxo-4H-chroMen-7-yloxy]-ethyl}-2-Methoxy-phenyl)-oxalaMic acid
• CAS No.: 949495-67-4
• Molecular Formula: C₂₉H₂₆N₂O₁₀
• Molecular Weight: 562.533
• Mol file: 949495-67-4.mol

Synonyms:

Chemical Property of N-(4-{2-[5-Hydroxy-2-(4-Methoxy-benzylcarbaMoyl)-4-oxo-4H-chroMen-7-yloxy]-ethyl}-2-Methoxy-phenyl)-oxalaMic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-{2-[5-Hydroxy-2-(4-Methoxy-benzylcarbaMoyl)-4-oxo-4H-chroMen-7-yloxy]-ethyl}-2-Methoxy-phenyl)-oxalaMic acid

There total 12 articles about N-(4-{2-[5-Hydroxy-2-(4-Methoxy-benzylcarbaMoyl)-4-oxo-4H-chroMen-7-yloxy]-ethyl}-2-Methoxy-phenyl)-oxalaMic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl ({2-methoxy-4-[2-({5-hydroxy-2-[(4-methoxybenzylamino)carbonyl]-4-oxo-4H-chromen-7-yl}oxy)ethyl]phenyl}amino)(oxo)acetate (949495-64-1) → C29H26N2O10 (949495-67-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm070336k

Reference yield:

2-[2-(3-methoxy-4-nitrophenyl)ethoxy]tetrahydro-2H-pyran (949495-52-7) → C29H26N2O10 (949495-67-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 76 percent / H₂ / Pd/C / methanol / 20 °C

2: 99 percent / DIPEA / CH₂Cl₂ / 2 h / 20 °C

3: 76 percent / methanol / p-toluenesulfonic acid / 1 h / 55 °C

4: 68 percent / DIAD; triphenylphosphine / CH₂Cl₂ / 20 °C

5: 61 percent / aq. LiOH / tetrahydrofuran / 20 °C

With methanol; lithium hydroxide; di-isopropyl azodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; 4: Mitsunobu reaction;

DOI:10.1021/jm070336k

Reference yield:

2-(3-methoxy-4-nitrophenyl)ethanol (168766-15-2) → C29H26N2O10 (949495-67-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.83 h / 20 °C

2: 76 percent / H₂ / Pd/C / methanol / 20 °C

3: 99 percent / DIPEA / CH₂Cl₂ / 2 h / 20 °C

4: 76 percent / methanol / p-toluenesulfonic acid / 1 h / 55 °C

5: 68 percent / DIAD; triphenylphosphine / CH₂Cl₂ / 20 °C

6: 61 percent / aq. LiOH / tetrahydrofuran / 20 °C

With methanol; lithium hydroxide; di-isopropyl azodicarboxylate; hydrogen; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; 5: Mitsunobu reaction;

DOI:10.1021/jm070336k

upstream raw materials:

ethyl ({2-methoxy-4-[2-({5-hydroxy-2-[(4-methoxybenzylamino)carbonyl]-4-oxo-4H-chromen-7-yl}oxy)ethyl]phenyl}amino)(oxo)acetate

2-(3-methoxy-4-nitrophenyl)ethanol

2-[2-(3-methoxy-4-nitrophenyl)ethoxy]tetrahydro-2H-pyran

{2-methoxy-4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]phenyl}amine