ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE

Base Information

• Chemical Name: ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE
• CAS No.: 890100-51-3
• Molecular Formula: C₁₂H₁₀O₃S₂
• Molecular Weight: 266.342
• Mol file: 890100-51-3.mol

Synonyms:

Chemical Property of ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE

Chemical Property:

• Vapor Pressure: 3.25E-07mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-thenoyl-2-thiophenecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE

There total 2 articles about ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-(ethoxycarbonyl)thiophene-2-ylzinc bromide (352530-37-1) + 2-Thiophenecarbonyl chloride (5271-67-0) → ethyl 5-(thiophene-2-carbonyl)thiophene-2-carboxylate (890100-51-3)

Guidance literature:

With bis(acetylacetonate)nickel(II); In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2011.01.135

Reference yield: 68.0%

2-Thiophenecarbonyl chloride (5271-67-0) + ethyl 5-bromothiophene-2-carboxylate (5751-83-7) → ethyl 5-(thiophene-2-carbonyl)thiophene-2-carboxylate (890100-51-3)

Guidance literature:

ethyl 5-bromothiophene-2-carboxylate; With diisobutylaluminum chloride; In tetrahydrofuran; at -78 ℃; Inert atmosphere; Schlenk technique;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

2-Thiophenecarbonyl chloride; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; hexane; at -40 - 25 ℃; Inert atmosphere;

DOI:10.1039/c3cc43356k

upstream raw materials:

5-(ethoxycarbonyl)thiophene-2-ylzinc bromide

2-Thiophenecarbonyl chloride

ethyl 5-bromothiophene-2-carboxylate

Refernces

• 1、 Kim, Seung-Hoi,Rieke, Reuben D.. "Preparation of aryl ketones via Ni-catalyzed Negishi-coupling reactions with acid chlorides". experimental part. p. 1523 - 1526. Retrieved 2011/05/16.