2-Di(tert-butyloxycarbonyl)-L-hoMoserine tert-Butyl Ester

Base Information

• Chemical Name: 2-Di(tert-butyloxycarbonyl)-L-hoMoserine tert-Butyl Ester
• CAS No.: 945744-04-7
• Molecular Formula: C₁₈H₃₃NO₇
• Molecular Weight: 375.463
• Mol file: 945744-04-7.mol

Synonyms:

Chemical Property of 2-Di(tert-butyloxycarbonyl)-L-hoMoserine tert-Butyl Ester

Chemical Property:

• Boiling Point: 443.6±55.0 °C(Predicted)
• PKA: 14.58±0.10(Predicted)
• Density: 1.099±0.06 g/cm3(Predicted)
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

2-Di(tert-butyloxycarbonyl)-L-homoserinetert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the preparation of aspartyl aldehyde derivative and labelled L-Glutamine (G597000).

Technology Process of 2-Di(tert-butyloxycarbonyl)-L-hoMoserine tert-Butyl Ester

There total 9 articles about 2-Di(tert-butyloxycarbonyl)-L-hoMoserine tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-Bis(tert-butoxycarbonyl)-L-aspartic acid α-tert-butyl ester (269733-22-4) → tert-butyl N,N-bis(tert-butyloxycarbonyl)-L-homoserinate (945744-04-7)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran;

DOI:10.1016/S0040-4039(02)01844-0

Reference yield: 98.0%

1-tert-butyl 4-methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butanedioate (395095-60-0) → tert-butyl N,N-bis(tert-butyloxycarbonyl)-L-homoserinate (945744-04-7)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; for 1h;

DOI:10.1016/j.tet.2007.03.163

Reference yield:

tert-butyl L-2-[bis(tert-butoxycarbonyl)amino]-4-oxo-butanoate (481053-32-1) → tert-butyl N,N-bis(tert-butyloxycarbonyl)-L-homoserinate (945744-04-7)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 1h;

upstream raw materials:

N,N-Bis(tert-butoxycarbonyl)-L-aspartic acid α-tert-butyl ester

1-tert-butyl 4-methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butanedioate

di-tert-butyl dicarbonate

4-benzyl 1-t-butyl L-aspartate

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