N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide

Base Information

• Chemical Name: N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide
• CAS No.: 916052-80-7
• Molecular Formula: C₁₁H₁₃ClN₂O
• Molecular Weight: 224.69
• Mol file: 916052-80-7.mol

Synonyms:

Chemical Property of N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide

Chemical Property:

• Boiling Point: 439.6±35.0 °C(Predicted)
• PKA: 13.99±0.70(Predicted)
• Density: 1.371±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-Amino-4-chlorophenyl)cyclobutanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide

There total 4 articles about N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Chloro-3-nitroaniline (635-22-3) + Cyclobutanecarbonyl chloride (5006-22-4) → N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide (916052-80-7)

Guidance literature:

4-Chloro-3-nitroaniline; Cyclobutanecarbonyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

With potassium carbonate; In methanol; water;

With hydrogen; Raney nickel; In methanol; for 18h; under 760.051 Torr;

Reference yield: 100.0%

C11H11ClN2O3 (1286584-86-8) → N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide (916052-80-7)

Guidance literature:

With hydrogen; nickel; In methanol; for 18h; under 760.051 Torr;

Reference yield:

Cyclobutanecarbonyl chloride (5006-22-4) → N-(3-amino-4-chlorophenyl)cyclobutanecarboxamide (916052-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: hydrogen / Raney_.(R). nickel / methanol / 760.05 Torr

With pyridine; hydrogen; Raney nickel; In methanol; dichloromethane;

upstream raw materials:

4-Chloro-3-nitroaniline

Cyclobutanecarbonyl chloride

C₁₁H₁₁ClN₂O₃