(S)-6-hydroxydecanoic acid

Base Information

• Chemical Name: (S)-6-hydroxydecanoic acid
• CAS No.: 1385031-35-5
• Molecular Formula: C₁₀H₂₀O₃
• Molecular Weight: 188.267
• Mol file: 1385031-35-5.mol

Synonyms:

Chemical Property of (S)-6-hydroxydecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-hydroxydecanoic acid

There total 4 articles about (S)-6-hydroxydecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(S)-N-methyl-6-hydroxydecanamide (1385031-32-2) → (S)-6-hydroxydecanoic acid (1385031-35-5)

Guidance literature:

(S)-N-methyl-6-hydroxydecanamide; With sodium hydroxide; In methanol; at 90 ℃;

With phosphoric acid; water; at 0 ℃; optical yield given as %ee;

DOI:10.3987/COM-12-12426

Reference yield:

ε-decalactone (5579-78-2,80445-36-9) → (S)-6-hydroxydecanoic acid (1385031-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium acetate / tetrahydrofuran / 20 °C

2.1: Pseudomonas cepacia lipase / hexane / 40 h / 50 °C / Resolution of racemate; Enzymatic reaction

3.1: sodium hydroxide / methanol / 90 °C

3.2: 0 °C

With Pseudomonas cepacia lipase; potassium acetate; sodium hydroxide; In tetrahydrofuran; methanol; hexane;

DOI:10.3987/COM-12-12426

Reference yield:

N-methyl-6-hydroxydecanamide (1385031-17-3) → (S)-6-hydroxydecanoic acid (1385031-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Pseudomonas cepacia lipase / hexane / 40 h / 50 °C / Resolution of racemate; Enzymatic reaction

2.1: sodium hydroxide / methanol / 90 °C

2.2: 0 °C

With Pseudomonas cepacia lipase; sodium hydroxide; In methanol; hexane;

DOI:10.3987/COM-12-12426

upstream raw materials:

ε-decalactone

(S)-N-methyl-6-acetoxydecanamide

(S)-N-methyl-6-hydroxydecanamide

N-methyl-6-hydroxydecanamide

Downstream raw materials:

(S)-ε-decalactone