6-(Methylsulfonyl)nicotinamidine

Base Information

• Chemical Name: 6-(Methylsulfonyl)nicotinamidine
• CAS No.: 859987-11-4
• Molecular Formula: C₇H₉N₃O₂S
• Molecular Weight: 199.233
• Mol file: 859987-11-4.mol

Synonyms:

Chemical Property of 6-(Methylsulfonyl)nicotinamidine

Chemical Property:

• Density: 1.48

Purity/Quality:

99% ^*data from raw suppliers

6-(Methylsulfonyl)nicotinimidamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(Methylsulfonyl)nicotinamidine

There total 6 articles about 6-(Methylsulfonyl)nicotinamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(methylsulfonyl)nicotinonitrile (66154-68-5) → 6-methanesulfonyl-nicotinamidine (859987-11-4)

Guidance literature:

With 1,4-dioxane; hydrogenchloride; ethanol; at 0 ℃; anschliessendes Behandeln des in Aethanol geloesten Reaktionsprodukts mit wss. NH₄Cl bei 37grad;

DOI:10.1039/jr9480001939

Reference yield:

6-sulfanylpyridine-3-carbonitrile (27885-58-1) → 6-methanesulfonyl-nicotinamidine (859987-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₃I; aq.-ethanolic NaOH

2: acetone; aqueous H₂SO₄; KMnO₄

3: ethanol; HCl; dioxane / 0 °C / anschliessendes Behandeln des in Aethanol geloesten Reaktionsprodukts mit wss. NH₄Cl bei 37grad

With 1,4-dioxane; hydrogenchloride; sodium hydroxide; potassium permanganate; ethanol; sulfuric acid; acetone; methyl iodide;

DOI:10.1039/jr9480001939

Reference yield:

6-(methylthio)nicotinonitrile (408350-80-1) → 6-methanesulfonyl-nicotinamidine (859987-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone; aqueous H₂SO₄; KMnO₄

2: ethanol; HCl; dioxane / 0 °C / anschliessendes Behandeln des in Aethanol geloesten Reaktionsprodukts mit wss. NH₄Cl bei 37grad

With 1,4-dioxane; hydrogenchloride; potassium permanganate; ethanol; sulfuric acid; acetone;

DOI:10.1039/jr9480001939

upstream raw materials:

6-(methylsulfonyl)nicotinonitrile

6-sulfanylpyridine-3-carbonitrile

6-(methylthio)nicotinonitrile

6-mercapto-nicotinamide