H-pyrrolo[1,2-b]pyridazine-6-carboxylic acid

Base Information

• Chemical Name: H-pyrrolo[1,2-b]pyridazine-6-carboxylic acid
• CAS No.: 118768-13-1
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.148
• Mol file: 118768-13-1.mol

Synonyms:

Chemical Property of H-pyrrolo[1,2-b]pyridazine-6-carboxylic acid

Chemical Property:

• PKA: -0.15±0.41(Predicted)
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Pyrrolo[1,2-b]pyridazine-6-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-pyrrolo[1,2-b]pyridazine-6-carboxylic acid

There total 4 articles about H-pyrrolo[1,2-b]pyridazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylic acid 7-tert-butyl ester 5,6-dimethyl ester (249513-32-4) → pyrrolo[1,2-b]pyridazine-6-carboxylic acid (118768-13-1)

Guidance literature:

pyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylic acid 7-tert-butyl ester 5,6-dimethyl ester; With water; potassium hydroxide; at 60 ℃;

With hydrogenchloride; at 80 ℃;

Reference yield: 62.0%

pyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylic acid (120266-84-4) → pyrrolo[1,2-b]pyridazine-6-carboxylic acid (118768-13-1)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 4h;

Reference yield:

trimethyl pyrrolo<1,2-b>pyridazine-5,6,7-tricarboxylate (7593-57-9) → pyrrolo[1,2-b]pyridazine-6-carboxylic acid (118768-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH

2: aqueous HCl

With hydrogenchloride; potassium hydroxide;

DOI:10.1021/jo01113a012

upstream raw materials:

pyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylic acid

trimethyl pyrrolo<1,2-b>pyridazine-5,6,7-tricarboxylate

1-(2-methoxy-2-oxoethyl)pyridazin-1-ium bromide

pyrrolo[1,2-b]pyridazine-5,6,7-tricarboxylic acid 7-tert-butyl ester 5,6-dimethyl ester

Downstream raw materials:

pyrrolo[1,2-b]pyridazine-6-ylmethanol

methyl pyrrolo[1,2-b]pyridazine-6-carboxylate

Refernces

• 1、 -. "SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS". Paragraph 00542-00543. . Retrieved 2015/05/19.