9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide

Base Information

Chemical Name:9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide
CAS No.:102977-55-9
Molecular Formula:C₂₀H₂₇N₇O₁₃P₂S
Molecular Weight:667.487
Hs Code.:

Synonyms:

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Chemical Property of 9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide

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Technology Process of 9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide

There total 2 articles about 9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83161-83-5
2-β-D-ribofuranosylthiazole-4-carboxamide 5'-phosphate

: 102977-55-9
9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide; methanol / 3.5 h

2: 1.) tri-n-butylamine, 2.) triethylamine / 1.) DMF, RT, 48 h, 2.) water, 24 h, pH 10

With tributyl-amine; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00159a027

Reference yield:

: 22257-15-4
ACP

: Imidazol-1-yl-phosphonic acid mono-[(2R,3S,4R,5R)-5-(4-carbamoyl-thiazol-2-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester

: 102977-55-9
9-(5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)adenine 6'<*>5' ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide

Guidance literature:: With tributyl-amine; triethylamine; Yield given. Multistep reaction; 1.) DMF, RT, 48 h, 2.) water, 24 h, pH 10;
DOI:10.1021/jm00159a027