Lafutidine IMpuritiy B

Base Information

• Chemical Name: Lafutidine IMpuritiy B
• CAS No.: 174583-84-7
• Molecular Formula: C₂₂H₂₉N₃O₅S
• Molecular Weight: 447.555
• Mol file: 174583-84-7.mol

Synonyms:

Chemical Property of Lafutidine IMpuritiy B

Chemical Property:

• Melting Point: 64 - 66°C
• Boiling Point: 715.2±60.0 °C(Predicted)
• PKA: 12?+-.0.46(Predicted)
• Density: 1.256±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Dichloromethane (Slightly), Methanol (Slightly)

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

LafutidineSulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Lafutidine Sulfone is the sulfonyl impurity of histamine H2-receptor antagonist, Lafutidine (L168500).

Technology Process of Lafutidine IMpuritiy B

There total 1 articles about Lafutidine IMpuritiy B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

2-[(furan-2-yl)methanesulfonyl]acetic acid (4-nitrophenyl)ester + (2Z)-4-({4-[(piperidin-1-yl)methyl]pyridin-2-yl}oxy)but-2-en-1-amine → 2-[(furan-2-yl)methanesulfonyl]-N-[(2Z)-4-({4-[(piperidin-1-yl)methyl]pyridin-2-yl}oxy)but-2-en-1-yl]acetamide (174583-84-7)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 - 5 ℃; for 2h; Concentration;