5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline

Base Information

• Chemical Name: 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline
• CAS No.: 171619-73-1
• Molecular Formula: C₁₃H₁₇BrN₂O₂
• Molecular Weight: 313.194
• Mol file: 171619-73-1.mol

Synonyms:

Chemical Property of 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline

There total 3 articles about 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-Bromo-1,2,3,4-tetrahydro-8-nitroisoquinoline (156694-04-1) + butanone (78-93-3) → 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline (171619-73-1)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; for 168h; Ambient temperature;

DOI:10.1021/jm00019a003

Reference yield:

5-bromoisoquinoline (34784-04-8) → 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline (171619-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / KNO₃, H₂SO₄

2: 1.) MeSO₃H, 2.) NaBH₄, formic acid / 1.) CHCl₃, reflux, 48 h, 2.) 30 min

3: 71 percent / 5 N methanolic HCl, NaCNBH₃ / 168 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; formic acid; methanesulfonic acid; sulfuric acid; sodium cyanoborohydride; potassium nitrate;

DOI:10.1021/jm00019a003

Reference yield:

5-bromo-8-nitroisoquinoline (63927-23-1) → 5-bromo-2-(1-methylpropyl)-1,2,3,4-tetrahydro-8-nitroisoquinoline (171619-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) MeSO₃H, 2.) NaBH₄, formic acid / 1.) CHCl₃, reflux, 48 h, 2.) 30 min

2: 71 percent / 5 N methanolic HCl, NaCNBH₃ / 168 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; formic acid; methanesulfonic acid; sodium cyanoborohydride;

DOI:10.1021/jm00019a003

upstream raw materials:

5-Bromo-1,2,3,4-tetrahydro-8-nitroisoquinoline

butanone

5-bromoisoquinoline

5-bromo-8-nitroisoquinoline