Epi NorgalanthaMine

Base Information

• Chemical Name: Epi NorgalanthaMine
• CAS No.: 156040-03-8
• Molecular Formula: C₁₆H₁₉NO₃
• Molecular Weight: 273.332
• Mol file: 156040-03-8.mol

Synonyms:

Chemical Property of Epi NorgalanthaMine

Chemical Property:

• Solubility.: Dichloromethane, Methanol

Purity/Quality:

Epi Norgalanthamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Epinorgalanthamine is a Epigalanthamine (E588025) derivative isolated from Crinum asiaticum var. japonicum. A metabolite of Galanthamine (G188500) in rats, dogs and humans.

Technology Process of Epi NorgalanthaMine

There total 35 articles about Epi NorgalanthaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

FeSO4.7H2O + Galantamine (357-70-0) → N-desmethyl galantamine (41303-74-6,156040-03-8)

Guidance literature:

With hydrogenchloride; In chloroform; water; 3-chloro-benzenecarboperoxoic acid;

Reference yield: 84.0%

(±)-nornarwedine → (±)-norgalanthamine (41303-52-0,41303-74-6,156040-03-8)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1016/j.bmc.2013.11.026

Reference yield: 76.0%

galanthamine N-oxide (596828-90-9) → N-desmethyl galantamine (41303-74-6,156040-03-8)

Guidance literature:

With iron(II) sulfate; In methanol; at 10 ℃; for 1.5h;

DOI:10.1016/S0040-4039(97)01097-6

upstream raw materials:

galanthamine N-oxide

galanthamine N-oxide

C₁₆H₁₇NO₃

[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

Downstream raw materials:

galanthamine

Refernces

• 1、 Bartolucci, Cecilia,Haller, Lars A.,Jordis, Ulrich,Fels, Gregor,Lamba, Doriano. "Probing Torpedo californica acetylcholinesterase catalytic Gorge with two novel bis-functional galanthamine derivatives". . p. 745 - 751. Retrieved 2010.
• 2、 Kimura, Hiroyuki,Kawai, Tomoki,Hamashima, Yoshio,Kawashima, Hidekazu,Miura, Kenji,Nakaya, Yuta,Hirasawa, Makoto,Arimitsu, Kenji,Kajimoto, Tetsuya,Ohmomo, Yoshiro,Ono, Masahiro,Node, Manabu,Saji, Hideo. "Synthesis and evaluation of (-)- and (+)-[11C]galanthamine as PET tracers for cerebral acetylcholinesterase imaging". . p. 285 - 291. Retrieved 2014.